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KMID : 1145120200180020257
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Asian Journal of Beauty and Cosmetology
2020 Volume.18 No. 2 p.257 ~ p.263
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Effect on Lanshi Tonic in Mice with Kidney-Yang Deficiency
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Liu Shuo
Ma Si-yao
Zhu Wenyi
Liang Jia
Shi Yu-Jing
Meng Hong
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Abstract
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Purpose: To study the regulatory effect of Lanshi tonic on kidney-yang deficiency model and its related mechanism.
Methods: ICR mice were randomly divided into five groups according to body weight: normal group, model group, Lanshi tonic high, medium and low dose group. Mice with kidney-yang deficiency syndrome were induced by hydrocortisone sodium succinate by intraperitoneal injection, 50 mg/kg for 7 days. At the same time, all groups were given corresponding medicine by oral administration for 10 days. The body mass, hair color and body shape of mice were observed and recorded. Spleen index, thymus index and adrenal index were calculated. Level of urine 17-OHCS was measured by ELISA. Level of serum Cortisol, ACTH, cAMP, cGMP and ratio of cAMP/cGMP were measured by ELISA.
Results: Compared with the normal group, the above indexes of the model group mice were significantly lower (p<0.05, p<0.01), except the serum cGMP was significantly higher (p<0.01). Compared with the model group, Lanshi tonic at high and medium doses had no significant change in urine 17-OHCS content (p>0.05), but had different improvement effects on the other indicators mentioned above (p<0.05, p<0.01).
Conclusion: Lanshi tonic can regulate the state of kidney-yang deficiency, which may be related to the regulation of adrenocortical secretion function and the imbalance of cyclic nucleotide levels.
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KEYWORD
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Lanshi tonic, Hydrocortisone sodium succinate, Kidney-yang deficiency, Adrenal cortex, Cyclic nucleotide
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